Neurology: A Queen Square Textbook, second edition, is a fully revised and updated companion that demonstrates the rapid pace of advancement within clinical neurology and applied neurosciences
A comprehensive and practical overview of current developments within clinical neurology, synthesising clinical neurology with translational research
Expertly edited and written by neurologists, neuroscientists and neurosurgeons working at Queen Square, advised by an distinguished International Editor team to present a global perspective
Introductory chapters summarise the basic sciences underpinning the practice of clinical neurology, including genetics, channelopathies, immunology, neurophysiology and neuropathology
All chapters fully revised and updated to reflect the increasing role of neurologists in acute care
Includes new contributions concerning major developments in the care of; stroke, epilepsy, dementia, Parkinson's disease, multiple sclerosis, neuromuscular disease, headache, infections, spinal disease, cranial nerve disease, neuropsychiatry, neurogenetics, neuro-oncology, uroneurology, neuro-otology, neuro-ophthalmology, pain medicine, sleep medicine, metabolic disease, drugs and toxins, autonomic disease, systemic disease, and neurorehabilitationfor dementia, epilepsy, headaches, neuro-genetics and many more
Contents
Editorial Team vii
Principal Editors vii
International Editors vii
Specialist Advisory Editors vii
Authors vii
Beginnings xi
Foreword to the First Edition xiii
Foreword to the Second Edition xv
Preface xvii
Acknowledgements xix
1 Neurology Worldwide: The Epidemiology and Burden of Neurological Disease 1
Simon Shorvon
2 Nervous System Structure and Function 11
Charles Clarke and Roger Lemon
3 Mechanisms of Neurological Disease: Genetics, Autoimmunity and Ion Channels 69
Dimitri Kullmann, Henry Houlden and Michael Lunn
4 The Language of Neurology: Symptoms, Signs and Basic Investigations 97
Charles Clarke, Matthew Adams, Robin Howard, Martin Rossor, Simon Shorvon and Jason Warren
5 Stroke and Cerebrovascular Diseases 133
Nicholas Losseff, Matthew Adams, Martin M. Brown, Joan Grieve and Robert Simister
6 Movement Disorders 187
Kailash Bhatia, Carla Cordivari, Mark Edwards, Thomas Foltynie, Marwan Hariz, Prasad Korlipara, Patricia Limousin, Niall Quinn, Sarah Tabrizi and Thomas Warner
7 Epilepsy and Related Disorders 221
Simon Shorvon, Beate Diehl, John Duncan, Matthias Koepp, Fergus Rugg ]Gunn, Josemir Sander, Matthew Walker and Tim Wehner
8 Dementia and Cognitive Impairment 289
Martin Rossor, John Collinge, Nick Fox, Simon Mead, Catherine Mummery, Jonathan Rohrer, Jonathan Schott and Jason Warren
9 Infection in the Nervous System 337
Robin Howard, Carmel Curtis and Hadi Manji
10 Nerve and Muscle Disease 391
Michael Lunn, Michael Hanna, Robin Howard, Matthew Parton, Shamima Rahman, Mary Reilly, Katie Sidle and Christopher Turner
11 Multiple Sclerosis and Demyelinating Diseases 475
Siobhan Leary, Gavin Giovannoni, Robin Howard, David Miller and Alan Thompson
12 Headache 513
Manjit Matharu, Paul Shanahan and Tim Young
13 Cranial Nerve Disorders 531
Jeremy Chataway, Charles Clarke, Robin Howard and Paul Jarman
14 Neuro ]Ophthalmology 553
James Acheson, Fion Bremner, Elizabeth Graham, Robin Howard, Alexander Leff, Gordon Plant, Simon Shorvon and Ahmed Toosy
15 Neuro ]Otology: Problems of Dizziness, Balance and Hearing 605
Rosalyn Davies, Linda M. Luxon, Doris ]Eva Bamiou and Adolfo Bronstein
16 Spinal Column and Spinal Cord Disorders 647
Simon Farmer and David Choi
17 Cerebellar Ataxias and Related Conditions 685
Nicholas W. Wood
18 Restorative Neurology, Rehabilitation and Brain Injury 699
Richard Greenwood, Diana Caine, Ulrike Hammerbeck, Alexander Leff, Diane Playford, Valerie Stevenson and
Nick Ward
19 Toxic, Metabolic and Physical Insults to the Nervous System and Inherited Disorders of Metabolism 729
Robin Howard, Jeremy Chataway, Mark Edwards, Simon Heales, Robin Lachmann, Alexander Leff and Elaine Murphy
20 Disorders of Consciousness, Intensive Care Neurology and Sleep 797
Robin Howard, Sofia Eriksson, Nicholas Hirsch, Neil Kitchen, Dimitri Kullmann, Christopher Taylor and Matthew Walker
21 Neuro ]Oncology 849
Jeremy Rees, Robert Bradford, Sebastian Brandner, Naomi Fersht, Rolf Jäger and Elena Wilson
22 Neuropsychiatry 905
Eileen Joyce
23 Pain 919
Paul Nandi
24 Autonomic Aspects of Neurology 945
Christopher Mathias, Gordon Ingle and Valeria Iodice
25 Uroneurology 967
Jalesh Panicker
26 Systemic Conditions and Neurology 985
David Werring, Robin Howard and Simon Shorvon
Index 1029
