Landmark Papers in Allergy

The increasing incidence and prevalence of allergic disease worldwide is one of the most remarkable phenomena of the past 50 years. One in three people in developed countries will experience an allergic condition at some point in their lives and advances in understanding the causes of this trend, and in allergy treatment and care, have captured the imagination of scientists, clinicians and the public. Landmark Papers in Allergy is a definitive collection of over 90 papers charting key discoveries and scientific advances in relation to allergy and the development of treatment and care for allergic disorders. Comprehensive in its coverage, the book includes the first clear descriptions of allergic diseases; the major advances in treatments, such as the discovery of antihistamines, cortisone, biological therapies and immunotherapy; the great immunological advances, such as the discovery of immunoglobulin E (IgE) and leukotrienes; the possible factors behind the increase in allergy, such as the house dust mite, changes in hygiene and diet; and the growing understanding of the social, psychological and quality-of-life consequences of allergy. Including authoritative commentaries from leading international experts providing reflections on the historical importance and current relevance of each landmark paper, Landmark papers in Allergy is essential reading for any clinician or academic with an interest in allergy. Table of Contents SECTION I: 1800-1899 ; 1. Did Bostock Discover Allergic Rhinitis? ; 2. Early Insights into the Characteristics of Asthma ; 3. Identifying Asthma Triggers ; 4. Innovative Experiments Which Helped to Unravel the Aetiological Basis of Hay Fever ; 5. Asthma Enters the Medical Mainstream ; SECTION II: 1900-1949 ; 6. What's in a Name? First Use of the Term 'Allergy' ; 7. An Innovative Treatment for Food Allergy ; 8. Laying the Foundation for Specific Immunotherapy ; 9. Celebrating the Case Study: Schloss' Description of Atopic Dermatitis ; 10. Richet's Nobel Lecture ; 11. A Serendipitous Discovery ; 12. Cooke's Early Insights into the Potentially Curative Role of Immunotherapy for Hay Fever ; 13. . Does Eczema Have an Allergic Aetiology? ; 14. ...and What about Angioedema and Urticaria? ; 15. Prausnitz, Kustner and the First Diagnostic Test for Allergy ; 16. Introducing Atopy ; 17. Ephedra - Laying the Foundations for Modern Autonomic Pharmacology ; 18. First Attempts to Unravel the Relationship between Diet and Allergy ; 19. Demonstrating Serological Changes Induced by Ragweed Extract ; 20. Bovet's Nobel Prize-winning Discovery of Antihistamines ; 21. Identification of Slow-Reacting Substance ; 22. Oral Allergy Syndrome ; SECTION III: 1950-1999 ; 23. In Praise of Famous Men: Early Cortisone Studies ; 24. The Relationship between Mast Cells and Histamine ; 25. What Goes Round Comes Around: Developing Allergen Immunotherapy ; 26. Burnet, Clonal Selection Theory and Acquired Immunological Tolerance ; 27. Slow-Reacting Substance of Anaphylaxis ; 28. Loveless and Wasp-venom Immunotherapy ; 29. Developing an Understanding of Mast Cell Biology ; 30. Disodium Cromoglycate for Allergic Asthma ; 31. Ancient Egyptian Soup for Treating Asthma: Cox and Intal ; 32. RAST: The Iconic Test for Allergic Sensitisation ; 33. The Discovery of IgE ; 34. Penicillin Allergy: A Model for Practical Clinical Translational Science ; 35. Unravelling the Relationship between Dermatophagoides Pteronyssinus and Asthma ; 36. The Gell and Coombs Classification ; 37. The Dawn of Molecular Allergology ; 38. Immunotherapy Can Change the Natural History of Respiratory Allergy ; 39. Anatomy of the Asthmatic Bronchi ; 40. Identifying a Novel Cause of Occupational Allergy ; 41. Delayed Hypersensitivity to Pollen Allergens ; 42. Inhaled Beclomethasone Dipropionate: Stepping-up Asthma Care ; 43. Challenging Notions of the "Atopic Personality" ; 44. Establishing and Investigating the Relationship between Food Allergy and Asthma ; 45. The "Histamine-Inhalational Test" ; 46. Allergic Reactions to Colloid Infusions-Another Chapter in the Colloid Debate ; 47. Total and Specific IgE and Allergic Bronchopulmonary Aspergillosis ; 48. Immunotherapy for Venom Allergy Comes of Age ; 49. Extending the Evidence for Immunotherapy to the Management of Children with House Dust Mite Triggered Asthma ; 50. Insights from Xhosa into Environmental Risk Factors for the Development of Asthma ; 51. Viral Infection, Allergic Sensitisation and Asthma ; 52. Immune Responses in Atopic Eczema ; 53. . Understanding the Relationship between Atopic Sensitisation and Airway Hyper-responsiveness in Asthma ; 54. Key Insights into the Relationship between Food Allergy and Atopic Dermatitis ; 55. From Slow-Reacting Substance of Anaphylaxis to Anti-Leukotrienes ; 56. Once More unto the Breach: the Role of the Damaged Bronchial Epithelium in Asthma ; 57. Management of Anaphylactic Shock ; 58. The Hygiene Hypothesis ; 59. In Search of the Elixir for Childhood Allergy and Asthma ; 60. A New Way of Considering 'Quality of Life' ; 61. Food Allergy and Anaphylaxis ; 62. Allergen Avoidance: The Isle of Wight Study ; 63. Introducing Sputum Counts ; 64. Atopic Asthma is a TH2-cell Mediated Disease ; 65. Investigating the Impact of Hay Fever on Educational Performance ; 66. Findings from an Early Peanut Immunotherapy Trial ; 67. Auto-Immune Mechanisms in Chronic Urticaria ; 68. Air Pollution, Mortality and the Need for Public Health Policy ; 69. The Geography of Asthma and Atopy: After the Berlin Wall Came Down ; 70. The Role of Animal Allergens in Allergic Disease ; 71. The Natural History of Wheezing: the Tucson Cohort ; 72. Measuring Food-Specific IgE Values ; 73. Tuberculosis Exposure and Atopy ; 74. The Inner-City Home Environment and Asthma ; 75. Mapping the Burden of Allergic Disease in Childhood: ISAAC ; 76. The Relationship between Obesity and Asthma ; 77. The Emergence of Monoclonal Antibodies ; 78. The Renaissance in Allergen Immunotherapy ; 79. Pet Exposure in Early Life and the Development of Allergy and Asthma ; SECTION IV: 2000-2012 ; 80. Predicting the Development of Childhood Asthma ; 81. IL-5 Blocking Monoclonal Antibody ; 82. Learning from Anaphylaxis Fatalities ; 83. Peanut Allergy and Quality of Life ; 84. The Janus Face of Endotoxin: for Good and Bad? ; 85. Testing the 'Hygiene Hypothesis': Probiotics for the Primary Prevention of Atopic Eczema ; 86. The Impact of Food Allergy on Health-Related Quality of Life ; 87. Does Idiopathic Eosinophilic Esophagitis have an Allergic Aetiology? ; 88. Dawn of the Genomic Age for Asthma ; 89. Endotoxins, Allergy and Tolerance ; 90. Inherited Skin-Barrier Defects and Risk of Developing 'Atopic' Eczema ; 91. Anti-IgE: Biologicals Reach the Inner-cities ; 92. Conclusions: From the 18th to the 21st Century, and Beyond...