This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of neoplastic and nonneoplastic diseases of the digestive tract and accessory organs such as the pancreas and liver, it incorporates the most recent clinical, pathological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, Diagnostic Pathology: Hepatobiliary and Pancreas is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.
Table of Contents:
SECTION 1: LIVER
INHERITED, METABOLIC, AND DEVELOPMENTAL DISORDERS
4 Glycogen Storage Disease, Hepatic
Joseph Misdraji, MD, Lisa Yerian, MD, and Grace E. Kim, MD
10 Tyrosinemia
Joseph Misdraji, MD
12 Niemann-Pick Disease
Joseph Misdraji, MD
14 Gaucher Disease
Joseph Misdraji, MD
16 Neonatal Hemochromatosis
Joseph Misdraji, MD
18 Porphyrin Metabolism Disorders
Maria Westerhoff, MD and Joseph Misdraji, MD
24 Dubin-Johnson Syndrome
Joseph Misdraji, MD and Sanjay Kakar, MD
26 Gilbert Disease
Joseph Misdraji, MD and Sanjay Kakar, MD
28 Progressive Familial Intrahepatic Cholestasis
Joseph Misdraji, MD
36 Cystic Fibrosis, Hepatic
Joseph Misdraji, MD
40 Hereditary Hemochromatosis
Joseph Misdraji, MD and Laura W. Lamps, MD
44 Wilson Disease
Joseph Misdraji, MD and Laura W. Lamps, MD
50 Alpha-1-Antitrypsin Deficiency
Nicole C. Panarelli, MD, Kari D. Caradine, MD, and Laura
W. Lamps, MD
54 Congenital Hepatic Fibrosis
Romil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD
56 Polycystic Liver Disease
Romil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD
58 Caroli Disease
Romil Saxena, MBBS, MD, FRCPath (UK)
INFECTIOUS DISORDERS
60 Overview of Hepatitis
Nicole C. Panarelli, MD and Laura W. Lamps, MD
66 Acute Viral Hepatitis
Nicole C. Panarelli, MD and Lisa Yerian, MD
70 Hepatitis B
Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD
74 Hepatitis C
Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD
78 Hepatitis E
Maria Westerhoff, MD
82 Epstein-Barr Virus
Laura W. Lamps, MD, Maria Westerhoff, MD, and Hanlin
L. Wang, MD, PhD
86 Cytomegalovirus
Laura W. Lamps, MD
88 Herpes Simplex Virus
Sanjay Kakar, MD
90 Adenovirus
Maria Westerhoff, MD and Hanlin L. Wang, MD, PhD
92 Pyogenic Abscess
Laura W. Lamps, MD
96 Sepsis in Liver
Laura W. Lamps, MD
98 Mycobacterium tuberculosis
Laura W. Lamps, MD
102 Atypical Mycobacteria
Laura W. Lamps, MD
106 Cat-Scratch Disease
Laura W. Lamps, MD
108 Candidiasis
Laura W. Lamps, MD
110 Histoplasmosis
Joseph Misdraji, MD and Laura W. Lamps, MD
114 Cryptococcosis
Laura W. Lamps, MD
116 Amebiasis
Laura W. Lamps, MD
120 Schistosomiasis
Laura W. Lamps, MD
122 Echinococcosis
Laura W. Lamps, MD
CHRONIC CHOLESTATIC AND AUTOIMMUNE DISORDERS
124 Autoimmune Hepatitis
Nicole C. Panarelli, MD and Lisa Yerian, MD
130 Primary Biliary Cholangitis
Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD
136 Primary Sclerosing Cholangitis
Hanlin L. Wang, MD, PhD
142 Ischemic Cholangitis
Maria Westerhoff, MD and Lisa Yerian, MD
144 Large Bile Duct Obstruction
Maria Westerhoff, MD and Laura W. Lamps, MD
148 Idiopathic Adulthood Ductopenia
Hanlin L. Wang, MD, PhD
PEDIATRIC CHOLESTATIC DISORDERS
150 Biliary Atresia
Romil Saxena, MBBS, MD, FRCPath (UK), Grace E. Kim, MD, and Matthew M. Yeh, MD, PhD
154 Idiopathic Neonatal Hepatitis
Romil Saxena, MBBS, MD, FRCPath (UK), Grace E. Kim, MD, and Matthew M. Yeh, MD, PhD
156 Syndromic Paucity of Intrahepatic Bile Ducts
(Alagille Syndrome)
Joseph Misdraji, MD, Romil Saxena, MBBS, MD, FRCPath (UK), and Matthew M. Yeh, MD, PhD
160 Nonsyndromic Paucity of Intrahepatic Bile Ducts
Romil Saxena, MBBS, MD, FRCPath (UK), Joseph Misdraji, MD, and Matthew M. Yeh, MD, PhD
DRUG/TOXIN-RELATED HEPATITIS
164 Drug-Related Acute Hepatitis
Sanjay Kakar, MD
170 Drug-Induced Acute Hepatic Failure
Sanjay Kakar, MD
174 Drug-Induced Cholestatic Liver Injury
Sanjay Kakar, MD
176 Drug-Related Granulomatous Hepatitis
Laura W. Lamps, MD
180 Drug-Related Steatohepatitis/Phospholipidosis
Laura W. Lamps, MD
184 Reye Syndrome
Romil Saxena, MBBS, MD, FRCPath (UK) and Lisa Yerian, MD
186 Drug-Related Cholangitis/Ductopenia
Maria Westerhoff, MD
192 Hepatic Stellate Cell Hyperplasia
Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD
FATTY LIVER DISEASES
194 Alcoholic Liver Disease
Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD
200 Nonalcoholic Steatohepatitis
Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD
208 Glycogenic Hepatopathy
Maria Westerhoff, MD and Lisa Yerian, MD
210 Fatty Liver of Pregnancy
Nicole C. Panarelli, MD and Lisa Yerian, MD
VASCULAR DISORDERS
212 Portal Venous Obstruction
Hanlin L. Wang, MD, PhD
214 Hepatoportal Sclerosis
Hanlin L. Wang, MD, PhD
216 Hepatic Venous Outflow Obstruction
Sanjay Kakar, MD
220 Venoocclusive Disease
Sanjay Kakar, MD
222 Amyloidosis
Sanjay Kakar, MD
224 Ischemia
Rondell Graham, MBBS and Lisa Yerian, MD
226 Nodular Regenerative Hyperplasia
Sanjay Kakar, MD
TRANSPLANTATION PATHOLOGY
228 Ischemia Reperfusion Injury
Romil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD
230 Antibody-Mediated Rejection
Hanlin L. Wang, MD, PhD and Romil Saxena, MBBS, MD, FRCPath (UK)
232 T-Cell-Mediated Rejection (Acute Cellular Rejection)
Romil Saxena, MBBS, MD, FRCPath (UK)
236 Chronic Rejection
Romil Saxena, MBBS, MD, FRCPath (UK) and Matthew M. Yeh, MD, PhD
238 Central Perivenulitis/Parenchymal Rejection
Rondell Graham, MBBS
240 Hepatic Artery Thrombosis
Rondell Graham, MBBS and Lisa Yerian, MD
242 Graft-vs.-Host Disease
Rondell Graham, MBBS and Lisa Yerian, MD
TUMORS OF THE LIVER
244 Hepatic Adenoma
Sanjay Kakar, MD and Matthew M. Yeh, MD, PhD
252 Focal Nodular Hyperplasia
Sanjay Kakar, MD
256 Regenerative and Dysplastic Nodules
Sanjay Kakar, MD
262 Hepatocellular Carcinoma and Variants
Sanjay Kakar, MD
274 Fibrolamellar Carcinoma
Rondell Graham, MBBS
278 Combined Hepatocellular-Cholangiocarcinoma
Maria Westerhoff, MD
282 Hepatoblastoma
Rondell Graham, MBBS
286 Bile Duct Adenoma
Rondell Graham, MBBS and Sanjay Kakar, MD
288 von Meyenburg Complex (Biliary Microhamartoma) Sanjay Kakar, MD, Laura W. Lamps, MD, and Rondell Graham, MBBS
290 Mucinous Cystic Neoplasm, Liver
Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD
294 Intrahepatic Cholangiocarcinoma
Rondell Graham, MBBS and Sanjay Kakar, MD
298 Intrahepatic Cholangiocarcinoma Histologic Subtypes
Rondell Graham, MBBS
302 Intraductal Papillary Neoplasm
Rondell Graham, MBBS
304 Hemangioma
Rondell Graham, MBBS
306 Angiomyolipoma
Rondell Graham, MBBS and Lisa Yerian, MD
310 Hepatic Small Vessel Neoplasm/Anastamosing Hemangioma
Maria Westerhoff, MD
314 Epithelioid Hemangioendothelioma
Sanjay Kakar, MD
316 Infantile Hemangioma
Sanjay Kakar, MD
318 Angiosarcoma
Sanjay Kakar, MD
320 Mesenchymal Hamartoma
Nicole C. Panarelli, MD, Hanlin L. Wang, MD, PhD, and Sanjay Kakar, MD
322 Embryonal Sarcoma
Nicole C. Panarelli, MD
324 Inflammatory Pseudotumor
Joseph Misdraji, MD
330 Segmental Atrophy (Nodular Elastosis)
Joseph Misdraji, MD
332 Hepatectomy Specimen Handling
Rondell Graham, MBBS and Laura W. Lamps, MD
MISCELLANEOUS HEPATIC DISORDERS
334 Langerhans Cell Histiocytosis
Maria Westerhoff, MD and Hanlin L. Wang, MD, PhD
338 Hemophagocytic Syndromes
Hanlin L. Wang, MD, PhD
DEVELOPMENTAL/CONGENITAL
342 Congenital Pancreatic Cyst
Hanlin L. Wang, MD, PhD
344 Cystic Fibrosis, Pancreas
Hanlin L. Wang, MD, PhD
346 Nesidioblastosis
Hanlin L. Wang, MD, PhD
348 Choledochal Cyst
Romil Saxena, MBBS, MD, FRCPath (UK) and Laura W. Lamps, MD
350 Cholelithiasis
Laura W. Lamps, MD
352 Acute Cholecystitis
Sanjay Kakar, MD
354 Chronic Cholecystitis
Sanjay Kakar, MD
356 Xanthogranulomatous Cholecystitis
Laura W. Lamps, MD
358 Eosinophilic Cholecystitis
Laura W. Lamps, MD
360 Polyarteritis Nodosa and Other Vasculitides
Nicole C. Panarelli, MD
362 Parasitic Infection
Laura W. Lamps, MD
NONNEOPLASTIC AND INFLAMMATORY DISORDERS OF THE PANCREAS
366 Acute Pancreatitis
Grace E. Kim, MD and Alyssa M. Krasinskas, MD
368 Chronic Pancreatitis
Alyssa M. Krasinskas, MD and Lisa Yerian, MD
372 Autoimmune Pancreatitis
Alyssa M. Krasinskas, MD and Lisa Yerian, MD
376 Groove Pancreatitis
Alyssa M. Krasinskas, MD, Lisa Yerian, MD, and Vikram Deshpande, MD
378 Infectious Pancreatitis
Laura W. Lamps, MD
380 Pseudocysts
Alyssa M. Krasinskas, MD, Vikram Deshpande, MD, and Lisa Yerian, MD
382 Diabetes Mellitus
Laura W. Lamps, MD
384 Lymphoepithelial Cyst of the Pancreas
Alyssa M. Krasinskas, MD and Lisa Yerian, MD
TUMORS OF THE GALLBLADDER AND EXTRAHEPATIC BILIARY TREE
386 Noninvasive Epithelial Polypoid Lesions
390 Nicole C. Panarelli, MD and Sanjay Kakar, MD
Carcinoma of Gallbladder
396 Nicole C. Panarelli, MD and Laura W. Lamps, MD
Carcinoma of Extrahepatic Bile Ducts
402 Rondell Graham, MBBS and Laura W. Lamps, MD
Squamous/Adenosquamous Carcinoma, Gallbladder
404 Hanlin L. Wang, MD, PhD
Neuroendocrine Neoplasms of Gallbladder
408 Hanlin L. Wang, MD, PhD
Granular Cell Tumor
410 Nicole C. Panarelli, MD
Embryonal Rhabdomyosarcoma
412 Hanlin L. Wang, MD, PhD
Adenomyoma
414 Nicole C. Panarelli, MD and Lisa Yerian, MD
Nonneoplastic Polypoid Gallbladder Lesions
Nicole C. Panarelli, MD and Laura W. Lamps, MD
TUMORS OF THE PANCREAS
418 Pancreatic Intraepithelial Neoplasia
Alyssa M. Krasinskas, MD and Sanjay Kakar, MD
420 Ductal Adenocarcinoma, Including Variants Alyssa M. Krasinskas, MD, Sanjay Kakar, MD, and Mari Mino-Kenudson, MD
424 Undifferentiated Carcinoma
Wei Zheng, MD, Sanjay Kakar, MD, and Alyssa M. Krasinskas, MD
426 Adenosquamous Carcinoma, Pancreas
Alyssa M. Krasinskas, MD
428 Serous Cystadenoma
Sanjay Kakar, MD and Grace E. Kim, MD
432 Acinar Cell Cystadenoma
Maria Westerhoff, MD
436 Simple Mucinous Cyst
Maria Westerhoff, MD
438 Mucinous Cystic Neoplasm, Pancreas
Maria Westerhoff, MD
442 Intraductal Papillary Mucinous Neoplasm
Mari Mino-Kenudson, MD, Zaid Mahdi, MD, and Alyssa M. Krasinskas, MD
448 Intraductal Oncocytic Papillary Neoplasm
Alyssa M. Krasinskas, MD and Mari Mino-Kenudson, MD
450 Intraductal Tubulopapillary Neoplasm
Alyssa M. Krasinskas, MD and Mari Mino-Kenudson, MD
452 Acinar Cell Carcinoma
Laura W. Lamps, MD, Wei Zheng, MD, and Alyssa M. Krasinskas, MD
456 Pancreatoblastoma
Alyssa M. Krasinskas, MD, Laura W. Lamps, MD, and Matthew M. Yeh, MD, PhD
458 Dermoid Cyst
Zaid Mahdi, MD, Vikram Deshpande, MD, and Alyssa M. Krasinskas, MD
460 Poorly Differentiated Neuroendocrine Carcinoma,
Pancreas
Sanjay Kakar, MD
464 Well-Differentiated Neuroendocrine Tumor, Pancreas
Sanjay Kakar, MD
470 Solid-Pseudopapillary Tumors
Sanjay Kakar, MD
TUMORS OF THE AMPULLA
474 Ampullary Adenoma
Hanlin L. Wang, MD, PhD
476 Ampullary Adenocarcinoma and Variants
Hanlin L. Wang, MD, PhD
480 Well-Differentiated Neuroendocrine Tumor, Ampulla
Hanlin L. Wang, MD, PhD
482 Gangliocytic Paraganglioma
Maria Westerhoff, MD
SPECIMEN HANDLING, WHIPPLE
484 Specimen Handling, Whipple
Alyssa M. Krasinskas, MD and Laura W. Lamps, MD
