Spinal Cord Injury

Spinal Cord Injuries, the newest volume in the Handbook of Clinical Neurology series, offers a comprehensive and detailed overview of the rapidly evolving science and treatment of spinal cord injury. Advances in neuroimaging, surgical treatment and application of electrical stimulation are dramatically impacting the treatment and outcome of these injuries. It provides a clear introduction to the core science of spinal cord injury, as well as to exciting research investigating new treatment options. Coverage includes brain-machine interfaces, transcranial stimulation, new pharmacological strategies, use of olfactory ensheathing cells, stem cells and precursor cells, gene therapy and molecular target discovery. This volume is a great resource for neuroscience and clinical neurology research specialists and practicing neurologists seeking a clear reference to the science and treatment of spinal cord injury. Joost Verhaagen, Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands and John W. McDonald, III, Executive Vice President and Director, The International Center for Spinal Cord Injury, Baltimore, MD, USA Table of Contents: SECTION 1: Developmental and Anatomical Perspectives 1. Development and maturation of the spinal cord: implications of molecular and genetic defects       G.W.J. Hawryluk, C.A. Ruff and M.G. Fehlings 2. Anatomy and biomechanics of the spinal column and cord      V.J. Miele, M.M. Panjabi and E.C. Benzel SECTION 2  Diagnosis and Prognosis 3. Clinical diagnosis and prognosis following spinal cord injury      A.S. Burns, R.J. Marino, A.E. Flanders and H. Flett 4. Clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury     A.Curt and P.H. Ellaway 5. Concepts of aging with paralysis: implications for recovery and treatment      M. Wirz and V. Dietz 6. Advanced MRI strategies for assessing spinal cord injury      S.A. Smith, J.J. Pekar and P.C.M. van Zijl SECTION 3  Acute spinal cord injury: medical, surgical and rehabilitative management 7. Advances in the management of spinal cord and spinal column injuries      A. Taghva, D.J. Hoh and C.L. Lauryssen 8. Spinal cord injuries in children and adolescents     L.C. Vogel, R.R. Betz and M.J. Mulcahey 9. The changing landscape of spinal cord injury      N. Juknis, J.M. Cooper and O. Volshteyn 10. Surgical treatments to restore function control in spinal cord injury        M.W. Keith and A. Peljovich 11. Advances in the rehabilitation management of acute spinal cord injury       J.F. Ditunno, D.D. Cardenas, C. Formal and K. Dalal 12. Spasticity        V. Dietz and T. Sinkjaer 13. Disordered cardiovascular control after spinal cord injury        L.C. Weaver, J.C. Fleming, C.J. Mathias and A.V. Krassioukov 14. New concepts in the prevention of pressure sores       K. Bogie, H.L. Powell and C.H. Ho 15. Functional electrical stimulation for bladder, bowel and sexual function        G.H. Creasey and M.D. Craggs 16. Evidence based therapy for recovery of function after spinal cord injury       S. Harkema, A. Behrman and H. Barbeau 17. Functional electrical stimulation: restoration of respiratory function        R.P. Onders 18. Spinal cord stimulation: therapeutic benefits and movement generation after spinal cord        injury        C.H. Tator, K. Minassian and V.K. Mushahwar 19. Promoting optimal functioning in spinal cord injury: the role of rehabilitation       psychology       S.T. Wegener, L.L. Adams and D. Rohe SECTION 4  Chronic spinal cord injury - the changing perspective of neurorestorative rehabilitation, activity-based and surgical restoration therapies 20. The changing field of rehabilitation: optimizing spontaneous regeneration and functional        recovery        J.W. McDonald III, C.L. Sadowsky and A. Stampas 21. The longitudinal spinal cord injury: lessons from intra spinal plexus, cauda equina and        medullary conus lesions        T. Carlstedt and L. Havtorn 22. Post-traumatic syringomyelia       C.B. Shields, Y.P. Zhang and L.B.E. Shields 23. Post-traumatic deformity: prevention and management       J. Wilson and J.M. Buchowski SECTION 5  Preclinical research - bridging the gap between bench and bedside 24. Spinal cord injury clinical trials: translational process, review of past and proposed acute       trials with reference to recommended trial guidelines        J. Steeves and A. Blight 25. Translating preclinical approaches into human application        V. Dietz and A. Curt 26. Translational spinal cord injury research: preclinical guidelines and challenges        P.J. Reier, M.A. Lane, E.D. Hall, Y.D. Teng and D.R. Howland 27. Brain-machine interfaces and transcranial stimulation: future implications for directing       functional movement and improving function after spinal injury in humans       J.M. Carmena and L.G. Cohen 28. Approaches to repairing the damaged spinal cord: overview        D. Becker and J.W. McDonald III 29. Limiting spinal cord injury by pharmacological intervention       J.V. Priestley, A.T. Michael-Titus and W. Tetzlaff 30. Harmful and beneficial effects of inflammation after spinal cord injury: potential       therapeutic implications        S. David, R. López-Vales and V.W. Yong 31. Defeating inhibition of regeneration by scar and myelin components        J.W. Fawcett, M.E. Schwab, L. Montani, N., Brazda and H.W. Müller 32. Realising the maximum potential of Schwann cells to promote recovery from spinal cord       injury        M.B. Bunge and P. McGhee Wood 33. Repair of CNS lesions by transplantation of olfactory ensheathing cells       G. Raisman, S.C. Barnett and A. R amón-Cueto 34. Cell transplantation: stem cells and precursor cells        Q. Cao and S.R. Whittemore 35. Gene therapy, neurotrophic factors and spinal cord regeneration        A. Blesch, I. Fischer and M.H. Tuszynski 36. Scaffolds to promote spinal cord regeneration        S. Sakiyama-Elbert, P.J. Johnson, S.I. Hodgetts, G.W. Plant and A.R. Harvey 37. Molecular target discovery for neural repair in the functional genomics era        J. Verhaagen, R.E. van Kesteren, K.A.M. Bossers, H.D. MacGillavry, M.R. Mason and       A.B. Smit 38. Combination therapies        M. Oudega, E.J. Bradbury and M.S. Ramer