How to Prepare the Endometrium to Maximize Implantation Rates and IVF Success

The last step in the IVF treatment cycle, embryo transfer, is also the process with the highest failure rate. No matter how good the laboratory technique is, a successful pregnancy will not be achieved without meticulous preparation of the uterus to accept the embryo. This book reviews the scientific evidence on endometrial receptivity, including histological, hormonal, biochemical, and immunological factors. Practical and concise, it supports gynecologists and embryologists to make evidence-based decisions that can influence the success rates of implantation and live births. Part of a series of books offering treatments and strategies for fertility and conception to optimize IVF outcomes, this volume is for all clinicians and embryologists working in reproductive medicine.

    Practical and concise, this book reviews scientific evidence on endometrial receptivity to enable clinicians to take evidence-based decisions and optimize IVF outcomes
    Authored by experts in the field, this book provides a comprehensive review of all current, up-to-date knowledge on factors impacting the endometrium
    A detailed volume that is part of a four-book series on improving the success of IVF, with other volumes focusing on periconception health, the egg and embryo, and male and sperm factors

Table of Contents

1. Physiology of endometrial development through the cycle and implantation Annabelle Brennan and Martha Hickey
2. Molecular and cellular basis of human embryo implantation Guiying Nie and Eva Dimitriadis
3. Protein biomarkers of endometrial receptivity Tracey A. Edgell
4. Genetic markers of endometrial receptivity (GMER) Patricia Díaz-Gimeno and Juan A. Garcia-Velasco
5. Effects of superovulation on the endometrium Natalie Hannan and Jemma Evans
6. Screening the uterine microbiome prior to embryo transfer Inmaculada Moreno and Carlos Simon
7. Estrogen and progesterone support in ART: optimizing implantation Jamie Stanhiser and Steven L. Young
8. The role of hysteroscopy and endometrial scratch in improving endometrial receptivity Yuval Or and Zeev Shoham
9. Fibroids and polyps: their effect on implantation Beverley Vollenhoven and Sarah Hunt
10. Cleavage stage or blastocyst transfer: which is better? Jason Kasraie
11. Dummy embryo transfer Khaldoun Sharif and Gamal I. Serour
12. Does the type of catheter used for embryo transfer matter? Tia Hunjan, Shirin Khanjani and Stuart Lavery
13. Should all embryos be transferred in unstimulated cycles? Nikoletta Panagiotopoulou and Siladitya Bhattacharya
14. Rest after embryo transfer is unhelpful Giuseppe Botta and Gedis Grudzinska
15. Ectopic pregnancies – why do they happen? R. R. Chodankar and Andrew Horne
16. The role on NK cells in implantation after IVF and treatment strategies Norman Shreeve and Ashley Moffett
17. Sex and immune receptivity for embryo transfer David J. Sharkey and Sarah A. Robertson
18. Immunotherapy/IVIG, prednisolone and intralipid in IVF Ole Bjarne Christiansen and Kathinka Marie Nyborg
19. The role of heparin and aspirin to aid implantation Luciano Nardo and Tarique Salman
20. Early pregnancy loss: causes and prevention Shreeya Tewary and Jan J. Brosens
21. Is the endometrium in women with PCOS compromised? Terhi T. Piltonen.

Gab Kovacs is Professor in the Department of Obstetrics and Gynaecology at Monash University, Victoria. A Reproductive Gynecologist, he has forty years of experience in the treatment of subfertility including IVF, donor insemination, ovulation induction and reproductive surgery. He has a passion for teaching and has edited fourteen books for Cambridge University Press.

Lois Salamonsen is Professor at the Centre for Reproductive Health, Hudson Institute of Medical Research, and Department of Molecular Biosciences, Monash University, Victoria. She was elected Fellow of the Australian Academy of Sciences and Honorary Fellow of the Royal Australasian College of Obstetrics and Gynaecology in recognition of her contribution to women's health research. For thirty years, her research has focussed on the molecular events underpinning human endometrial function.